Analysis of Soluble Molecular Fibronectin-Fibrin Complexes and EDA-Fibronectin Concentration in Plasma of Patients with Atherosclerosis

Atherosclerosis, a chronic vascular disease, leads to molecular events bound with interplaying processes of inflammation and coagulation. In the present study, fibronectin (FN), FN containing extra domain A (EDA-FN), frequency of occurrence, and relative amounts of soluble plasma FN-fibrin complexes...

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Bibliographic Details
Published in:Inflammation 2016-06, Vol.39 (3), p.1059-1068
Main Authors: Lemańska-Perek, Anna, Krzyżanowska-Gołąb, Dorota, Pupek, Małgorzata, Klimeczek, Piotr, Witkiewicz, Wojciech, Kątnik-Prastowska, Iwona
Format: Article
Language:English
Subjects:
Atherosclerosis - blood
Biomedical and Life Sciences
Biomedicine
Cohort Studies
Coronary Artery Disease - diagnosis
Fibrin - metabolism
Fibronectins - blood
Fibronectins - metabolism
Humans
Immunology
Internal Medicine
Original
Original Article
Pathology
Pharmacology/Toxicology
Rheumatology
Risk
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Summary:Atherosclerosis, a chronic vascular disease, leads to molecular events bound with interplaying processes of inflammation and coagulation. In the present study, fibronectin (FN), FN containing extra domain A (EDA-FN), frequency of occurrence, and relative amounts of soluble plasma FN-fibrin complexes were analyzed in 80 plasma samples of patients suspected of coronary artery disease based on clinical evaluation and changes in arteries found by computed tomographic coronary angiography. The study showed that in the plasma of the patients’ group with high risk of coronary artery disease EDA-FN concentration was significantly higher (3.5 ± 2.5 mg/L; P  
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-016-0336-0