Health-Related Quality of Life in Children and Adolescents with Hereditary Bleeding Disorders and in Children and Adolescents with Stroke: Cross-Sectional Comparison to Siblings and Peers

• Published in: BioMed research international 2016-01, Vol.2016 (2016), p.1-8
• Main Authors: Frühwald, Michael, Nowak-Göttl, Ulrike, Reinke, Sarah, Krümpel, Anne, Kurnik, Karin, Klamroth, Robert, Funk, Stephanie, Holzhauer, Susanne, von Mackensen, Sylvia, Neuner, Bruno, Halimeh, Susan
• Format: Article
• Language: English
• Subjects: Adolescent; Age; Blood Coagulation Disorders - complications; Blood Coagulation Disorders - physiopathology; Blood Coagulation Disorders - psychology; Blood diseases; Child; Children & youth; Comparative analysis; Cross-Sectional Studies; Disease; Female; Genetic aspects; Health; Hematology; Hemophilia; Hospitals; Humans; Ischemia; Life expectancy; Linear Models; Male; Multivariate Analysis; Norms; Oncology; Pediatrics; Population; Quality of Life; Questionnaires; Siblings; Stroke; Stroke - complications; Stroke - physiopathology; Stroke - psychology; Studies; Surveys; Surveys and Questionnaires; Teenagers
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2016/1579428

Objectives. To investigate self-reported health-related quality of life (HrQoL) in children and adolescents with chronic medical conditions compared with siblings/peers. Methods. Group 1 (6 treatment centers) consisted of 74 children/adolescents aged 8–16 years with hereditary bleeding disorders (HBD), 12 siblings, and 34 peers. Group 2 (one treatment center) consisted of 70 children/adolescents with stroke/transient ischemic attack, 14 siblings, and 72 peers. HrQoL was assessed with the “revised KINDer Lebensqualitätsfragebogen” (KINDL-R) questionnaire. Multivariate analyses within groups were done by one-way ANOVA and post hoc pairwise single comparisons by Student’s t -tests. Adjusted pairwise comparisons were done by hierarchical linear regressions with individuals nested within treatment centers (group 1) and by linear regressions (group 2), respectively. Results. No differences were found in multivariate analyses of self-reported HrQoL in group 1, while in group 2 differences occurred in overall wellbeing and all subdimensions. These differences were due to differences between patients and peers. After adjusting for age, gender, number of siblings, and treatment center these differences persisted regarding self-worth ( p = . 0040 ) and friend-related wellbeing ( p < . 001 ). Conclusions. In children with HBD, HrQoL was comparable to siblings and peers. In children with stroke/TIA HrQoL was comparable to siblings while peers, independently of relevant confounder, showed better self-worth and friend-related wellbeing.