High frequency of central memory regulatory T cells allows detection of liver recipients at risk of early acute rejection within the first month after transplantation

Several studies have analyzed the potential of T regulatory cells (Treg cells) as biomarkers of acute rejection (AR). The aim of the present multicenter study was to correlate the percentage of peripheral Treg cells in liver graft recipients drawn at baseline up to 12 months after transplantation wi...

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Bibliographic Details
Published in:International immunology 2016-02, Vol.28 (2), p.55-64
Main Authors: Boix-Giner, Francisco, Millan, Olga, San Segundo, David, Muñoz-Cacho, Pedro, Mancebo, Esther, Llorente, Santiago, Rafael-Valdivia, Lourdes, Rimola, Antoni, Fábrega, Emilio, Mrowiec, Anna, Allende, Luis, Minguela, Alfredo, Bolarín, Jose M, Paz-Artal, Estela, López-Hoyos, Marcos, Brunet, Mercé, Muro, Manuel
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Aged
Antigens, CD - metabolism
Biomarkers - metabolism
Disease Progression
Female
Follow-Up Studies
Graft Rejection - diagnosis
Graft Rejection - immunology
Humans
Immunologic Memory
Liver Transplantation
Male
Middle Aged
Prognosis
Prospective Studies
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - metabolism
Young Adult
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Summary:Several studies have analyzed the potential of T regulatory cells (Treg cells) as biomarkers of acute rejection (AR). The aim of the present multicenter study was to correlate the percentage of peripheral Treg cells in liver graft recipients drawn at baseline up to 12 months after transplantation with the presence of AR. The percentage of central memory (cm) Treg cells (CD4(+)CD25(high)CD45RO(+)CD62L(+)) was monitored at pre-transplant and at 1 and 2 weeks, and 1, 2, 3 and 6 months and 1 year post-transplantation. The same validation standard operating procedures were used in all participating centers. Fifteen patients developed AR (23.4%). Hepatitis C virus recurrence was observed in 16 recipients, who displayed low peripheral blood cmTreg levels compared with patients who did not. A steady increase of cmTregs was observed during the first month after transplantation with statistically significant differences between AR and non-AR patients. The high frequency of memory Treg cells allowed us to monitor rejection episodes during the first month post-transplantation. On the basis of these data, we developed a prediction model for assessing risk of AR that can provide clinicians with useful information for managing patients individually and customizing immunosuppressive therapies.
ISSN:0953-8178
1460-2377
DOI:10.1093/intimm/dxv048