Prognostic value of ERG, PTEN, CRISP3 and SPINK1 in predicting biochemical recurrence in prostate cancer

The established prognostic factors associated with prostatic adenocarcinoma are the Gleason score, pathological T staging and serum prostatic-specific antigen (PSA) level. However, these prognostic factors alone are not sufficient for predicting prognostic characteristics, including early stage or a...

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Bibliographic Details
Published in:Oncology letters 2016-06, Vol.11 (6), p.3621-3630
Main Authors: NOH, BYEONG-JOO, SUNG, JI-YOUN, KIM, YOUN WHA, CHANG, SUNG-GOO, PARK, YONG-KOO
Format: Article
Language:English
Subjects:
Antigens
Biological markers
Biomarkers
Cancer
Cancer therapies
cysteine-rich secretory protein 3
Development and progression
Gene expression
Genetic aspects
Health aspects
Medical prognosis
Metastasis
Mortality
Multivariate analysis
Oncology
Phosphatase
phosphatase and tensin homolog
Properties
Prostate cancer
Proteins
Relapse
serine protease inhibitor Kazal type I
Standard deviation
transcriptional regulator ERG
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Summary:The established prognostic factors associated with prostatic adenocarcinoma are the Gleason score, pathological T staging and serum prostatic-specific antigen (PSA) level. However, these prognostic factors alone are not sufficient for predicting prognostic characteristics, including early stage or advanced prostate cancer, presence of metastasis or disease-related mortality. The purpose of the present study was to simultaneously evaluate the prognostic value and associations of four biomarkers, namely, transcriptional regulator ERG (ERG), phosphatase and tensin homolog (PTEN), cysteine-rich secretory protein 3 (CRISP3) and serine protease inhibitor Kazal type I (SPINK1), and to conduct risk stratification of prostate cancer for use in patient management. A total of 68 formalin-fixed, paraffin-embedded, prostate cancer samples from radical prostatectomies were obtained in the Kyung Hee University Hospital (Seoul, Korea) and were studied immunohistochemically for ERG, PTEN, CRISP3 and SPINK1 to determine the proportion and intensity of staining. SPINK1 expression was mutually exclusive of ERG expression (P=0.001). The loss of PTEN and high CRISP3 expression are unfavorable indicators for prostate cancer, as PTEN loss was associated with shorter biochemical recurrence (BCR) (P=0.039), and high CRISP3 expression was associated with increased BCR (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2016.4459