Significance of ETV6 rearrangement in acute promyelocytic leukemia with t(15;17)/promyelocytic leukemia/retinoic acid receptor alpha

Acute promyelocytic leukemia (APL) is a common subtype of acute myeloid leukemia in China. Since the application of arsenic trioxide and all-trans retinoic acid in the treatment of APL, the prognosis has greatly improved. However, ~20% of patients with APL relapse upon completing chemotherapy. Decre...

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Bibliographic Details
Published in:Oncology letters 2016-06, Vol.11 (6), p.3953-3960
Main Authors: GAO, NA, YU, WEN-ZHENG, WANG, XUE-XIA, SUN, JIAN-RONG, YU, NING, LIU, ZENG-YAN, LIU, XIAO-DAN, LIU, REN-TONG, FENG, RUI, DING, BU-TONG, SANG, TAN, GUO, NONG-JIAN
Format: Article
Language:English
Subjects:
acute promyelocytic leukemia
Antigens
Artificial chromosomes
Blood
Blood platelets
Bone marrow
Cell growth
Chemotherapy
Deoxyribonucleic acid
DNA
Ets variant 6 gene
Flow cytometry
Genetic variation
Health aspects
Hematology
Kinases
Laboratories
Leukemia
Medical prognosis
Mortality
Multivariate analysis
Patients
prognosis
rearrangement
split-signal FISH
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Summary:Acute promyelocytic leukemia (APL) is a common subtype of acute myeloid leukemia in China. Since the application of arsenic trioxide and all-trans retinoic acid in the treatment of APL, the prognosis has greatly improved. However, ~20% of patients with APL relapse upon completing chemotherapy. Decreasing the relapse rate and incidence of early mortality may pose the greatest challenges for the future management of APL. Recently, Ets variant 6 (ETV6) was reported to be involved in a variety of translocations associated with hematological malignancies of myeloid and lymphoid origin. To date, little is known about the clinical implication of ETV6 rearrangement in APL. In the present study, ETV6 rearrangement was examined by split-signal fluorescence in situ hybridization in 258 adults with APL, and its association with the clinical features and outcomes of the patients was analyzed. The data suggested that ETV6 rearrangement may be an independent unfavorable prognostic factor for overall survival in APL patients.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2016.4544