Clinicopathological and prognostic significance of sialyl Lewis X overexpression in patients with cancer: a meta-analysis

Many studies have shown that sialyl Lewis X (sLe(X)) is related to cancer prognosis and clinicopathology, but failed to provide conclusive results. We conducted the present meta-analysis to identify the association between sLe(X) overexpression and cancer prognosis. We searched studies in PubMed and...

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Bibliographic Details
Published in:OncoTargets and therapy 2016-01, Vol.9, p.3113-3125
Main Authors: Liang, Jin-Xiao, Liang, Yong, Gao, Wei
Format: Article
Language:English
Subjects:
Age
Antigens
Breast cancer
Cancer
Carbohydrates
Carcinogenesis
Care and treatment
Cell adhesion & migration
Colorectal cancer
Development and progression
Esophagus
Gene expression
Genetic aspects
Health aspects
Ligands
Lung cancer
Lymphatic system
Medical prognosis
Meta-analysis
Metastasis
Original Research
Patient outcomes
Studies
Survival analysis
Systematic review
Thoracic surgery
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Summary:Many studies have shown that sialyl Lewis X (sLe(X)) is related to cancer prognosis and clinicopathology, but failed to provide conclusive results. We conducted the present meta-analysis to identify the association between sLe(X) overexpression and cancer prognosis. We searched studies in PubMed and Embase databases. Relative risk or hazard ratio with 95% confidence intervals were estimated with the Mantel-Haenszel random-effect method and 29 studies were included. Our meta-analysis showed that sLe(X) overexpression is significantly related to lymphatic invasion, venous invasion, T stage, N stage, M stage, tumor stage, recurrence, and overall survival. In subgroup analysis, we found that cancer type and ethnicity might be two major contributing factors to the possible presence of heterogeneity among the studies. In conclusion, sLe(X) overexpression is associated with tumor metastasis, recurrence, and overall survival in cancer patients, it plays an important role in cancer prognosis.
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S102389