Nanotechnology for enrichment and detection of circulating tumor cells

Circulating tumor cells (CTCs) are a hallmark of invasive behavior of cancer, responsible for the development of metastasis. Their detection and analysis have significant impacts in cancer biology and clinical practice. However, CTCs are rare events and contain heterogeneous subpopulations, requirin...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2015-07, Vol.10 (12), p.1973-1990
Main Authors: Bhana, Saheel, Wang, Yongmei, Huang, Xiaohua
Format: Article
Language:English
Subjects:
Animals
Batch Cell Culture Techniques - methods
Cancer cells
Cancer research
Cell Separation - methods
Cell Tracking - methods
circulating tumor cells
detection
enrichment
functional nanoparticles
Humans
Identification and classification
Immunomagnetic Separation - methods
Magnetic Resonance Imaging - methods
Magnetite Nanoparticles - chemistry
microfluidics
nanostructured substrates
Nanotechnology
Neoplastic Cells, Circulating - chemistry
Neoplastic Cells, Circulating - pathology
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Summary:Circulating tumor cells (CTCs) are a hallmark of invasive behavior of cancer, responsible for the development of metastasis. Their detection and analysis have significant impacts in cancer biology and clinical practice. However, CTCs are rare events and contain heterogeneous subpopulations, requiring highly sensitive and specific techniques to identify and capture CTCs with high efficiency. Nanotechnology shows strong promises for CTC enrichment and detection owning to the unique structural and functional properties of nanoscale materials. In this review, we discuss the CTC enrichment and detection technologies based on a variety of functional nanosystems and nanostructured substrates, with the goal to highlight the role of nanotechnology in the advancement of basic and clinical CTC research.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm.15.32