Obstetric outcome and incidence of congenital anomalies in 2351 IVF/ICSI babies

Purpose The aim of this study was to provide a comprehensive follow-up of fetal and perinatal outcome and the incidence of congenital anomalies in babies born after fresh embryo transfers compared to those conceived spontaneously in infertile couples. Methods Retrospective comparative analysis of al...

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Published in:Journal of assisted reproduction and genetics 2016-06, Vol.33 (6), p.711-717
Main Authors: Levi Setti, Paolo Emanuele, Moioli, Melita, Smeraldi, Antonella, Cesaratto, Elisa, Menduni, Francesca, Livio, Stefania, Morenghi, Emanuela, Patrizio, Pasquale
Format: Article
Language:English
Subjects:
Adult
Assisted Reproduction Technologies
Congenital Abnormalities - epidemiology
Embryo Transfer - adverse effects
Embryos
Female
Fertility
Fertilization in Vitro - adverse effects
Gynecology
Human Genetics
Humans
In vitro fertilization
Incidence
Infertility
Infertility - complications
Male
Medicine
Medicine & Public Health
Multiple births
Obstetrics
Pregnancy
Pregnancy complications
Pregnancy Outcome
Pregnancy, Multiple
Reproductive Medicine
Reproductive technologies
Retrospective Studies
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Summary:Purpose The aim of this study was to provide a comprehensive follow-up of fetal and perinatal outcome and the incidence of congenital anomalies in babies born after fresh embryo transfers compared to those conceived spontaneously in infertile couples. Methods Retrospective comparative analysis of all clinical pregnancies from fresh cleavage-stage embryo transfer cycles (IVF and ICSI) compared with infertile patients who conceived spontaneously in the same time period (control). Congenital anomalies were classified following the European Surveillance of Congenital Anomalies (EUROCAT) classification. Results A total of 2414 assisted reproductive technology (ART) pregnancies were compared to 582 spontaneous conceptions in the control infertile group representing 2306 deliveries. No significant differences were found in pregnancy outcome between the two groups (delivery rate, abortion rate, ectopic pregnancies, medical abortions for fetal anomalies, single and twins mean gestational age, and weight at delivery). A significant difference ( p  
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-016-0714-4