Surgical Outcomes of Synchronous Multiple Primary Non-Small Cell Lung Cancers

The prognostic indicators for synchronous multiple primary non-small cell lung cancer (NSCLC) vary across reports. In present study, the prognostic factors for the patients with synchronous multiple primary NSCLC were analyzed in a large cohort. A total of 285 patients with synchronous multiple prim...

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Bibliographic Details
Published in:Scientific reports 2016-06, Vol.6 (1), p.23252-23252, Article 23252
Main Authors: Zhang, Zhirong, Gao, Shugeng, Mao, Yousheng, Mu, Juwei, Xue, Qi, Feng, Xiaoli, He, Jie
Format: Article
Language:English
Subjects:
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692/4028/546
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Adult
Aged
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - surgery
Disease-Free Survival
Female
Humanities and Social Sciences
Humans
Kaplan-Meier Estimate
Kidney Neoplasms - secondary
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Lymphatic Metastasis
Male
Middle Aged
multidisciplinary
Neoplasm Staging
Prognosis
Proportional Hazards Models
Science
Sex Factors
Tomography, X-Ray Computed
Treatment Outcome
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Summary:The prognostic indicators for synchronous multiple primary non-small cell lung cancer (NSCLC) vary across reports. In present study, the prognostic factors for the patients with synchronous multiple primary NSCLC were analyzed in a large cohort. A total of 285 patients with synchronous multiple primary NSCLC who underwent radical surgical resection and with complete follow-up information were included in this study. The Kaplan-Meier method were used for survival analysis, Cox proportional hazards regression models were used for risk factors evaluation. Among them, 94 (33.0%) patients had bilateral tumors and 51 (17.9%) had multiple (≥3) tumors. The 5-year disease-free survival (DFS) and overall survival (OS) rate was 58.7% and 77.6%, respectively. Univariate analysis identified parameters conferring shorter OS including male gender, symptomatic disease, negative family history, large maximal tumor size, not all adenocarcinomas, advanced highest T stage and lymph node involvement. Multivariate analysis showed that male gender (p = 0.020), symptomatic disease (p = 0.017) and lymph node involvement (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep23252