Whole-genome resequencing of honeybee drones to detect genomic selection in a population managed for royal jelly

Four main evolutionary lineages of A. mellifera have been described including eastern Europe (C) and western and northern Europe (M). Many apiculturists prefer bees from the C lineage due to their docility and high productivity. In France, the routine importation of bees from the C lineage has resul...

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Bibliographic Details
Published in:Scientific reports 2016-06, Vol.6 (1), p.27168-27168, Article 27168
Main Authors: Wragg, David, Marti-Marimon, Maria, Basso, Benjamin, Bidanel, Jean-Pierre, Labarthe, Emmanuelle, Bouchez, Olivier, Le Conte, Yves, Vignal, Alain
Format: Article
Language:English
Subjects:
45
45/43
45/77
631/208/212
631/208/457
Animals
Bees - genetics
Computer Science
Fatty Acids
Genetics, Population
Genome Size
Genome, Insect
Haploidy
Humanities and Social Sciences
Life Sciences
multidisciplinary
Pilot Projects
Polymorphism, Single Nucleotide
Science
Selection, Genetic
Whole Genome Sequencing - methods
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Summary:Four main evolutionary lineages of A. mellifera have been described including eastern Europe (C) and western and northern Europe (M). Many apiculturists prefer bees from the C lineage due to their docility and high productivity. In France, the routine importation of bees from the C lineage has resulted in the widespread admixture of bees from the M lineage. The haplodiploid nature of the honeybee Apis mellifera and its small genome size, permits affordable and extensive genomics studies. As a pilot study of a larger project to characterise French honeybee populations, we sequenced 60 drones sampled from two commercial populations managed for the production of honey and royal jelly. Results indicate a C lineage origin, whilst mitochondrial analysis suggests two drones originated from the O lineage. Analysis of heterozygous SNPs identified potential copy number variants near to genes encoding odorant binding proteins and several cytochrome P450 genes. Signatures of selection were detected using the hapFLK haplotype-based method, revealing several regions under putative selection for royal jelly production. The framework developed during this study will be applied to a broader sampling regime, allowing the genetic diversity of French honeybees to be characterised in detail.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep27168