The Circadian Clock in the Regulation of Renal Rhythms

Since the kidney is integral to maintenance of fluid and ion homeostasis, and therefore blood pressure regulation, its proper function is paramount. Circadian fluctuations in blood pressure, renal blood flow, glomerular filtration rate, and sodium and water excretion have been documented for decades...

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Bibliographic Details
Published in:Journal of biological rhythms 2015-12, Vol.30 (6), p.470-486
Main Authors: Solocinski, Kristen, Gumz, Michelle L.
Format: Article
Language:English
Subjects:
Animals
Biological clocks
Circadian Clocks - genetics
Circadian Clocks - physiology
Circadian rhythm
Circadian Rhythm - genetics
Circadian Rhythm - physiology
CLOCK Proteins - genetics
Gene Expression Regulation
Homeostasis - genetics
Humans
Hypertension - physiopathology
Ion Transport - genetics
Kidney - cytology
Kidney - physiology
Kidneys
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Summary:Since the kidney is integral to maintenance of fluid and ion homeostasis, and therefore blood pressure regulation, its proper function is paramount. Circadian fluctuations in blood pressure, renal blood flow, glomerular filtration rate, and sodium and water excretion have been documented for decades, if not longer. Recent studies on the role of circadian clock proteins in the regulation of a variety of renal transport genes suggest that the molecular clock in the kidney controls circadian fluctuations in renal function. The circadian clock appears to be a critical regulator of renal function with important implications for the treatment of renal pathologies, which include chronic kidney disease and hypertension. The development, regulation, and mechanism of the kidney clock are reviewed here.
ISSN:0748-7304
1552-4531
DOI:10.1177/0748730415610879