Improvement of parkinsonian features correlate with high plasma levodopa values after broad bean (Vicia faba) consumption

Five healthy volunteers and six patients with Parkinson's disease (PD) ate 250 g cooked broad beans after 12 hours without treatment. During the next four hours a substantial clinical improvement was noted, three patients showed severe dyskinesias, and plasma levodopa concentrations rose.

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1992-08, Vol.55 (8), p.725-727
Main Authors: Rabey, J M, Vered, Y, Shabtai, H, Graff, E, Korczyn, A D
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Bromocriptine - administration & dosage
Carbidopa - administration & dosage
Combined Modality Therapy
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Fabaceae - chemistry
Female
Humans
Levodopa - pharmacokinetics
Lisuride - administration & dosage
Male
Medical sciences
Middle Aged
Neurologic Examination - drug effects
Neurology
Parkinson Disease - blood
Parkinson Disease - diet therapy
Plants, Medicinal
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Description
Summary:Five healthy volunteers and six patients with Parkinson's disease (PD) ate 250 g cooked broad beans after 12 hours without treatment. During the next four hours a substantial clinical improvement was noted, three patients showed severe dyskinesias, and plasma levodopa concentrations rose.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.55.8.725