A Material Conferring Hemocompatibility

There is a need for biomimetic materials for use in blood-contacting devices. Blood contacting surfaces maintain their patency through physico-chemical properties of a functional endothelium. A poly(carbonate-urea) urethane (PCU) is used as a base material to examine the feasibility of L-Arginine me...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2016-06, Vol.6 (1), p.26848-26848, Article 26848
Main Authors: Everett, William, Scurr, David J, Rammou, Anna, Darbyshire, Arnold, Hamilton, George, de Mel, Achala
Format: Article
Language:English
Subjects:
631/45
692/308
Biomimetics
Blood
Chemical properties
Endothelium
Humanities and Social Sciences
Medical equipment
multidisciplinary
Nitric oxide
Polymers
Science
Smooth muscle
Transplants & implants
Urea
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There is a need for biomimetic materials for use in blood-contacting devices. Blood contacting surfaces maintain their patency through physico-chemical properties of a functional endothelium. A poly(carbonate-urea) urethane (PCU) is used as a base material to examine the feasibility of L-Arginine methyl ester (L-AME) functionalized material for use in implants and coatings. The study hypothesizes that L-AME, incorporated into PCU, functions as a bioactive porogen, releasing upon contact with blood to interact with endothelial nitric oxide synthase (eNOS) present in blood. Endothelial progenitor cells (EPC) were successfully cultured on L-AME functionalized material, indicating that L-AME -increases cell viability. L-AME functionalized material potentially has broad applications in blood-contacting medical devices, as well as various other applications requiring endogenous up-regulation of nitric oxide, such as wound healing. This study presents an in-vitro investigation to demonstrate the novel anti-thrombogenic properties of L-AME, when in solution and when present within a polyurethane-based polymer.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep26848