Modelling estimates of the burden of respiratory syncytial virus infection in children in the UK

ObjectiveThe burden of respiratory syncytial virus (RSV) illness is not well characterised in primary care. We estimated the burden of disease attributable to RSV in children in the UK between 1995 and 2009.DesignTime-series regression modelling.SettingA multiple linear regression model based on wee...

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Bibliographic Details
Published in:BMJ open 2016-06, Vol.6 (6), p.e009337-e009337
Main Authors: Taylor, Sylvia, Taylor, Robert J, Lustig, Roger L, Schuck-Paim, Cynthia, Haguinet, François, Webb, David J, Logie, John, Matias, Gonçalo, Fleming, Douglas M
Format: Article
Language:English
Subjects:
Adolescent
Age
Age Distribution
Anti-Bacterial Agents - therapeutic use
Antibiotics
Bronchitis
Child
Child, Preschool
Clinical medicine
Cost of Illness
Databases, Factual
Drug Prescriptions - statistics & numerical data
Female
Hospitalization
Hospitalization - statistics & numerical data
Hospitals
Humans
Incidence
Infant
Infant, Newborn
Infections
Infectious Diseases
Influenza
Laboratories
Linear Models
Male
Mortality
Otitis Media - epidemiology
Pathogens
Patients
Pneumonia
Population
Practice research
Primary care
Primary Health Care
Respiratory diseases
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - drug therapy
Respiratory Syncytial Virus Infections - epidemiology
Seasons
Surveillance
United Kingdom - epidemiology
Viral infections
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Summary:ObjectiveThe burden of respiratory syncytial virus (RSV) illness is not well characterised in primary care. We estimated the burden of disease attributable to RSV in children in the UK between 1995 and 2009.DesignTime-series regression modelling.SettingA multiple linear regression model based on weekly viral surveillance (RSV and influenza, Public Health England), and controlled for non-specific seasonal drivers of disease, estimated the proportion of general practitioner (GP) episodes of care (counted as first visit in a series within 28 days; Clinical Practice Research Datalink, CPRD), hospitalisations (Hospital Episode Statistics, HES) and deaths (Office of National Statistics, ONS) attributable to RSV each season.ParticipantsChildren 0–17 years registered with a GP in CPRD, or with a respiratory disease outcome in the HES or ONS databases.Primary outcome measuresRSV-attributable burden of GP episodes, hospitalisations and deaths due to respiratory disease by age. RSV-attributable burden associated with selected antibiotic prescriptions.ResultsRSV-attributable respiratory disease in the UK resulted in an estimated 450 158 GP episodes, 29 160 hospitalisations and 83 deaths per average season in children and adolescents, with the highest proportions in children
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2015-009337