Complexity and Specificity of the Neutrophil Transcriptomes in Juvenile Idiopathic Arthritis

NIH projects such as ENCODE and Roadmap Epigenomics have revealed surprising complexity in the transcriptomes of mammalian cells. In this study, we explored transcriptional complexity in human neutrophils, cells generally regarded as nonspecific in their functions and responses. We studied distinct...

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Bibliographic Details
Published in:Scientific reports 2016-06, Vol.6 (1), p.27453-27453, Article 27453
Main Authors: Hu, Zihua, Jiang, Kaiyu, Frank, Mark Barton, Chen, Yanmin, Jarvis, James N.
Format: Article
Language:English
Subjects:
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Arthritis
Bioinformatics
Cluster analysis
Disease
Gene expression
Genomes
Genomics
Humanities and Social Sciences
MicroRNAs
multidisciplinary
Neutrophils
Proteins
Science
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Summary:NIH projects such as ENCODE and Roadmap Epigenomics have revealed surprising complexity in the transcriptomes of mammalian cells. In this study, we explored transcriptional complexity in human neutrophils, cells generally regarded as nonspecific in their functions and responses. We studied distinct human disease phenotypes and found that, at the gene, gene isoform, and miRNA level, neutrophils exhibit considerable specificity in their transcriptomes. Thus, even cells whose responses are considered non-specific show tailoring of their transcriptional repertoire toward specific physiologic or pathologic contexts. We also found that miRNAs had a global impact on neutrophil transcriptome and are associated with innate immunity in juvenile idiopathic arthritis (JIA). These findings have important implications for our understanding of the link between genes, non-coding transcripts and disease phenotypes.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep27453