Changes in Systolic Blood Pressure over Time in Healthy Cats and Cats with Chronic Kidney Disease

Background Hypertension is a common problem in older cats, most often associated with chronic kidney disease (CKD). Cross‐sectional studies have suggested that blood pressure in cats increases with age. Hypothesis/Objectives To determine whether blood pressure in cats increases with age and whether...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2015-05, Vol.29 (3), p.855-861
Main Authors: Bijsmans, E.S., Jepson, R.E., Chang, Y.M., Syme, H.M., Elliott, J.
Format: Article
Language:English
Subjects:
Age
Animals
Blood pressure
Blood Pressure - physiology
Cat Diseases - physiopathology
Cats
Cats - physiology
Creatinine
Diagnosis
Feline
Female
Geriatrics
Hypertension
Hypertension - etiology
Hypertension - physiopathology
Hypertension - veterinary
Hyperthyroidism
Kidney diseases
Kidneys
Laboratories
Male
Plasma
Renal disease
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - physiopathology
Renal Insufficiency, Chronic - veterinary
Retrospective Studies
Risk Factors
Urine
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Summary:Background Hypertension is a common problem in older cats, most often associated with chronic kidney disease (CKD). Cross‐sectional studies have suggested that blood pressure in cats increases with age. Hypothesis/Objectives To determine whether blood pressure in cats increases with age and whether this occurs independently of the presence of CKD. To investigate risk factors for developing hypertension. Animals/Subjects Two hundred and sixty‐five cats with CKD and 133 healthy cats ≥9 years were retrospectively identified. Methods Four groups were created according to status at initial evaluation (CKD or healthy) and blood pressure at the last included visit (normotensive [NT] or developed hypertension [DH]): Healthy‐NT, Healthy‐DH, CKD‐NT and CKD‐DH. Systolic blood pressure (SBP) over time slopes were compared with 0 and between groups. Risk factors for the development of hypertension were investigated, and associations of biochemical and clinical variables with SBP were examined. Results Cats that were hypertensive at CKD diagnosis (n = 105) were not included in further analyses. Twenty‐seven cats with CKD and 9 healthy cats developed hypertension ≥3 months after diagnosis of CKD or their first visit. Systolic blood pressure significantly increased with age in all cats (P 
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.12600