Quantitative Accuracy of the Simplified Strong Ion Equation to Predict Serum pH in Dogs

Background Electrochemical approach to the assessment of acid‐base states should provide a better mechanistic explanation of the metabolic component than methods that consider only pH and carbon dioxide. Hypothesis/Objectives Simplified strong ion equation (SSIE), using published dog‐specific values...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2015-05, Vol.29 (3), p.781-785
Main Authors: Cave, N.J., Koo, S.T.
Format: Article
Language:English
Subjects:
Accuracy
Acid-Base Equilibrium
Acid-Base Imbalance - blood
Acid-Base Imbalance - veterinary
Acids
Acid‐base
Animal diseases
Animals
Biochemistry
Blood gas analysis
Blood Gas Analysis - methods
Blood Gas Analysis - veterinary
blood gases
blood serum
Canine
Carbon dioxide
Discordance
dissociation
Dog Diseases - blood
Dogs
Dogs - blood
Dogs - physiology
Electrochemical
Electrochemistry
Electrolytes
equations
Hydrogen-Ion Concentration
Metabolism
Plasma
Prospective Studies
Reproducibility of Results
Strong ion difference
Teaching hospitals
Variables
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Summary:Background Electrochemical approach to the assessment of acid‐base states should provide a better mechanistic explanation of the metabolic component than methods that consider only pH and carbon dioxide. Hypothesis/Objectives Simplified strong ion equation (SSIE), using published dog‐specific values, would predict the measured serum pH of diseased dogs. Animals Ten dogs, hospitalized for various reasons. Methods Prospective study of a convenience sample of a consecutive series of dogs admitted to the Massey University Veterinary Teaching Hospital (MUVTH), from which serum biochemistry and blood gas analyses were performed at the same time. Serum pH was calculated (Hcal+) using the SSIE, and published values for the concentration and dissociation constant for the nonvolatile weak acids (Atot and Ka), and subsequently Hcal+ was compared with the dog's actual pH (Hmeasured+). To determine the source of discordance between Hcal+ and Hmeasured+, the calculations were repeated using a series of substituted values for Atot and Ka. Results The Hcal+ did not approximate the Hmeasured+ for any dog (P = 0.499, r2 = 0.068), and was consistently more basic. Substituted values Atot and Ka did not significantly improve the accuracy (r2 = 0.169 to
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.12579