Evaluation of the Effects of a Therapeutic Renal Diet to Control Proteinuria in Proteinuric Non‐Azotemic Dogs Treated with Benazepril

BACKGROUND: Angiotensin‐converting enzyme inhibitors (ACEIs) are currently used to control proteinuria in dogs with chronic kidney disease. Renal diets (RDs) have beneficial effects in the management of azotemic dogs, but its role in proteinuric non‐azotemic (PNAz) dogs has been poorly documented. H...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2014-01, Vol.28 (1), p.30-37
Main Authors: Cortadellas, O, Talavera, J, Fernández del Palacio, M.J
Format: Article
Language:English
Subjects:
angiotensin-converting enzyme inhibitors
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Animals
aspirin
Azotemia
Benzazepines - therapeutic use
blood
Blood Cell Count - veterinary
Blood Chemical Analysis - veterinary
Blood Pressure
Canine
clinical examination
clinical trials
Creatinine
Creatinine - urine
diet
Dog Diseases - drug therapy
Dog Diseases - pathology
Dogs
Enzymes
Kidney
Kidney diseases
malnutrition
Nephrology
Original
Protein
proteinuria
Proteinuria - diet therapy
Proteinuria - veterinary
Renal Insufficiency, Chronic - drug therapy
Renal Insufficiency, Chronic - pathology
Renal Insufficiency, Chronic - veterinary
serum albumin
Serum Albumin - analysis
systolic blood pressure
t-test
therapeutics
urinalysis
Urinalysis - veterinary
Urine
Urology
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Summary:BACKGROUND: Angiotensin‐converting enzyme inhibitors (ACEIs) are currently used to control proteinuria in dogs with chronic kidney disease. Renal diets (RDs) have beneficial effects in the management of azotemic dogs, but its role in proteinuric non‐azotemic (PNAz) dogs has been poorly documented. HYPOTHESIS: Administration of a RD to PNAz dogs treated with benazepril (Be) improves proteinuria control compared with the administration of a maintenance diet (MD). ANIMALS: Twenty‐two PNAz (urine protein/creatinine ratio [UPC] >1) dogs. METHODS: Randomized open label clinical trial design. Dogs were assigned to group‐MD (5.5 g protein/100 kcal ME)/Be or to group‐RD (3.7 g protein/100 kcal ME)/Be group during 60 days. Dogs with serum albumin (Alb)
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.12246