Effect of Trilostane on Hormone and Serum Electrolyte Concentrations in Dogs with Pituitary‐Dependent Hyperadrenocorticism

BACKGROUND: The effects of trilostane on key hormones and electrolytes over 24 hours in dogs with pituitary‐dependent hyperadrenocorticism (PDH) are unknown. OBJECTIVES: To determine the plasma concentration of cortisol, endogenous adrenocorticotropic hormone (ACTH), aldosterone, sodium, potassium,...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2014-01, Vol.28 (1), p.160-165
Main Authors: Griebsch, C, Lehnert, C, Williams, G.J, Failing, K, Neiger, R
Format: Article
Language:English
Subjects:
Adrenal gland
Adrenocortical Hyperfunction - blood
Adrenocortical Hyperfunction - drug therapy
Adrenocortical Hyperfunction - physiopathology
Adrenocortical Hyperfunction - veterinary
Adrenocorticotropic Hormone - blood
aldosterone
Aldosterone - blood
Animals
blood serum
calcium
Calcium - blood
corticotropin
cortisol
Dihydrotestosterone - administration & dosage
Dihydrotestosterone - analogs & derivatives
Dihydrotestosterone - pharmacokinetics
Dihydrotestosterone - therapeutic use
Dog Diseases - blood
Dog Diseases - drug therapy
Dog Diseases - physiopathology
Dogs
electrolytes
Enzyme Inhibitors - administration & dosage
Enzyme Inhibitors - pharmacokinetics
Enzyme Inhibitors - therapeutic use
Female
Hormones
Hydrocortisone - blood
hyperadrenocorticism
Hypercortisolism
Male
medicine
Original
Plasma
potassium
Potassium - blood
Prospective Studies
renin
sodium
Sodium - blood
Treatment
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Summary:BACKGROUND: The effects of trilostane on key hormones and electrolytes over 24 hours in dogs with pituitary‐dependent hyperadrenocorticism (PDH) are unknown. OBJECTIVES: To determine the plasma concentration of cortisol, endogenous adrenocorticotropic hormone (ACTH), aldosterone, sodium, potassium, and ionized calcium concentrations, and plasma renin activity over a 24‐hour period after administration of trilostane to dogs with well‐controlled PDH. ANIMALS: Nine dogs (mean age 9.3 ± 0.67 years, mean weight 31.9 ± 6.4 kg) with confirmed PDH. METHODS: Prospective study. Thirty days after the first administration of trilostane, blood samples were taken at −30, 0 (baseline), 15, 30, 60, and 90 minutes, and 2, 3, 4, 6, 8, 12, 16, 20, and 24 hours after administration of trilostane and plasma concentration of cortisol, endogenous ACTH, aldosterone, sodium, potassium, ionized calcium, and renin activity were determined. RESULTS: Cortisol concentrations decreased significantly (P 
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.12268