Carbamazepine, serum thyroid hormones and myocardial function in epileptic patients

Serum thyroid hormone and thyrotropin levels were assayed and the myocardial function was evaluated by measuring systolic time intervals both in 30 patients with epilepsy on long-term carbamazepine monotherapy and in 19 healthy volunteers. Serum thyroxine, free thyroxine and triiodothyronine levels...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1993-06, Vol.56 (6), p.710-712
Main Authors: Isojärvi, J I, Airaksinen, K E, Repo, M, Pakarinen, A J, Salmela, P, Myllylä, V V
Format: Article
Language:English
Subjects:
Adult
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Carbamazepine - adverse effects
Carbamazepine - therapeutic use
Epilepsy - blood
Epilepsy - drug therapy
Epilepsy - physiopathology
Female
Heart - physiopathology
Humans
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Systole - physiology
Thyroxine - blood
Triiodothyronine - blood
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Summary:Serum thyroid hormone and thyrotropin levels were assayed and the myocardial function was evaluated by measuring systolic time intervals both in 30 patients with epilepsy on long-term carbamazepine monotherapy and in 19 healthy volunteers. Serum thyroxine, free thyroxine and triiodothyronine levels were significantly lower (p < 0.001) in the patient group than in the control group and systolic time intervals were similar in both groups.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.56.6.710