Aortic Wall Extracellular Matrix Proteins Correlate with Syntax Score in Patients Undergoing Coronary Artery Bypass Surgery

• Published in: The open cardiovascular medicine journal 2016-01, Vol.10 (1), p.48-56
• Main Authors: Chiong, Terri, Cheow, Esther S H, Woo, Chin C, Lin, Xiao Y, Khin, Lay W, Lee, Chuen N, Hartman, Mikael, Sze, Siu K, Sorokin, Vitaly A
• Format: Article
• Language: English
• ISSN: 1874-1924; 1874-1924
• DOI: 10.2174/1874192401610010048

The SYNTAX score correlate with major cardiovascular events post-revascularization, although the histopathological basis is unclear. We aim to evaluate the association between syntax score and extracellular matrix histological characteristics of aortic punch tissue obtained during coronary artery bypass surgery (CABG). This analysis compares coronary artery bypass surgery patients with High and Low syntax score which were followed up for one year period. Patients with High (score ≥ 33, (n=77)) and Low Syntax Scores (score ≤ 22, (n=71)) undergoing elective CABG were recruited prospectively. Baseline clinical characteristics and surgical risks were well matched. At 1 year, EMACCE (Sum of cardiovascular death, stroke, congestive cardiac failure, and limb, gut and myocardial ischemia) was significantly elevated in the High syntax group (P=0.022). Mass spectrometry (MS)-based quantitative iTRAQ proteomic results validated on independent cohort by immunohistochemistry (IHC) revealed that the High syntax group had significantly upraised Collagen I (P