Self-Microemulsifying Drug Delivery Systems: An Attractive Strategy for Enhanced Therapeutic Profile

Ease of administration and painless approach made oral route the most preferred. Poor oral bioavailability is pronounced with the majority of recent active ingredients because of dissolution rate limited absorption. Failure to attain intended therapeutic effect of the poor water soluble drugs by thi...

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Bibliographic Details
Published in:International scholarly research notices 2014, Vol.2014, p.964051-11
Main Authors: Akula, Samatha, Gurram, Aravind Kumar, Devireddy, Srinivas Reddy
Format: Article
Language:English
Subjects:
Drug delivery systems
Drug dosages
Drugs
Lipids
Microemulsions
Molecular weight
Particle size
Permeability
Pharmaceutical research
Review
Studies
Surfactants
Triglycerides
Vehicles
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Summary:Ease of administration and painless approach made oral route the most preferred. Poor oral bioavailability is pronounced with the majority of recent active ingredients because of dissolution rate limited absorption. Failure to attain intended therapeutic effect of the poor water soluble drugs by this route led to development of novel drug delivery systems which will fulfill therapeutic needs with minimum dose. Although many formulation approaches like solid dispersions, complexation, pH modification, and cocrystals exist, lipid based delivery systems finding increased appliance with the apparent increase in absorption of drug. Among lipid based formulations, self-microemulsifying formulations (droplet size 
ISSN:2356-7872
2356-7872
DOI:10.1155/2014/964051