Effects of Marine Phospholipids Extract on the Lipid Levels of Metastatic and Nonmetastatic Prostate Cancer Patients

High intake of omega-3 fatty acids (n-3 FAs) from fish has shown to reduce metastatic progression of prostate cancer. This clinical trial investigated the influence of high n-3 FA intake (marine phospholipids, MPL) on the FA composition of blood lipids, lysophosphatidylcholine (LPC), and on lipoprot...

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Bibliographic Details
Published in:International scholarly research notices 2014, Vol.2014, p.249204-12
Main Authors: Küllenberg de Gaudry, Daniela, Taylor, Lenka A., Kluth, Jessica, Hübschle, Tobias, Fritzsche, Jonas, Hildenbrand, Bernd, Pletschen, Lars, Schilli, Karin, Hodina, Arwen, Griffith, Lee S., Breul, Jürgen, Unger, Clemens, Massing, Ulrich
Format: Article
Language:English
Subjects:
Aged
Biosynthesis
Care and treatment
Clinical Study
Clinical trials
Enzymes
Fatty acids
Health aspects
Influence
Lipids
Lipoproteins
Metastasis
Mortality
Phospholipids
Prostate cancer
Triglycerides
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Summary:High intake of omega-3 fatty acids (n-3 FAs) from fish has shown to reduce metastatic progression of prostate cancer. This clinical trial investigated the influence of high n-3 FA intake (marine phospholipids, MPL) on the FA composition of blood lipids, lysophosphatidylcholine (LPC), and on lipoproteins in prostate cancer patients and elderly men without prostate cancer. MPL supplementation resulted in a significant increase of n-3 FAs (eicosapentaenoic and docosahexaenoic acid) in blood lipids, while arachidonic acid (n-6 FA) decreased significantly. Low density lipoprotein (LDL) and high density lipoprotein (HDL) increased significantly, but the LDL increase was observed only in subjects with an inactive tumour. Similarly, LPC plasma concentration increased significantly only in patients without tumour. The missing increase of LDL and LPC after MPL supplementation in patients with actively growing (metastasizing) prostate cancer suggests that tumour cells have an elevated demand for LDL and LPC. Due to the MPL-induced increase of n-3 FAs in these blood lipids, it can be assumed that especially actively growing and metastasizing prostate cancer cells are provided with elevated amounts of these antimetastatic n-3 FAs. A hypothetic model explaining the lower incidence of metastatic progression in prostate cancer patients with high fish consumption is presented.
ISSN:2356-7872
2356-7872
DOI:10.1155/2014/249204