Ichnocarpus frutescens Ameliorates Experimentally Induced Convulsion in Rats

The present study was carried out to evaluate the anticonvulsant activity and probable mechanism of action of the methanol root extract from I. frutescens (MEIF) using different experimental animal models. Anticonvulsant activity of the single dose of MEIF (100, 200, and 400 mg/kg, p.o.) was evaluat...

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Bibliographic Details
Published in:International scholarly research notices 2014, Vol.2014, p.434179-9
Main Authors: Singh, Narendra Kumar, Laloo, Damiki, Garabadu, Debapriya, Singh, Tryambak Deo, Singh, Virendra Pratap
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants
Antioxidants
Ayurvedic medicine
Consciousness
Convulsions
Drug therapy
Enzymes
Epilepsy
Health aspects
Herbal medicine
Oxidative stress
Pharmaceutical sciences
Risk factors
Rodents
Studies
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Summary:The present study was carried out to evaluate the anticonvulsant activity and probable mechanism of action of the methanol root extract from I. frutescens (MEIF) using different experimental animal models. Anticonvulsant activity of the single dose of MEIF (100, 200, and 400 mg/kg, p.o.) was evaluated in maximal electroshock- (MES-), pentylenetetrazole- (PTZ-), and isoniazid- (INH-) induced convulsions models in rats. The levels of γ-amino butyric acid (GABA), glutamate, GABA-transaminase (GABA-T) activity and oxidative stress markers were measured in pretreated rat’s brain homogenate to corroborate the mechanism of observed anticonvulsant activity. MEIF (200–400 mg/kg, p.o.) protected the animals in all the behavioral models used. Pretreatment of MEIF (200–400 mg/kg, p.o.) and diazepam (1.0 mg/kg, i.p.) to the animals in INH-induced convulsion model showed 100% and 80% protection, respectively, as well as significant restoration of GABA and glutamate level in the rat’s brain. MEIF and vigabatrin (50 mg/kg, i.p.) reduced the PTZ-induced increase in the activity of GABA-T (46%) in the brain. Further, MEIF reversed the PTZ-induced increase in lipid peroxidase (LPO) and decrease in reduced glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) activities. The findings of this study validate the anticonvulsant activity of I. frutescens.
ISSN:2356-7872
2356-7872
DOI:10.1155/2014/434179