Reassortment compatibility between PB1, PB2, and HA genes of the two influenza B virus lineages in mammalian cells

In addition to influenza A subtypes, two distinct lineages of influenza B virus also cause seasonal epidemics to humans. Recently, Dudas et al. have done evolutionary analyses of reassortment patterns of the virus and suggested genetic lineage relationship between PB1, PB2, and HA genes. Using genet...

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Bibliographic Details
Published in:Scientific reports 2016-06, Vol.6 (1), p.27480-27480, Article 27480
Main Authors: Kim, Jin Il, Lee, Ilseob, Park, Sehee, Bae, Joon-Yong, Yoo, Kirim, Lemey, Philippe, Park, Mee Sook, Song, Jin-Won, Kee, Sun-Ho, Song, Ki-Joon, Park, Man-Seong
Format: Article
Language:English
Subjects:
45
45/43
631/114/2785
631/326/596/1578
Genes
Humanities and Social Sciences
multidisciplinary
Phylogenetics
Science
Science (multidisciplinary)
Viruses
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Summary:In addition to influenza A subtypes, two distinct lineages of influenza B virus also cause seasonal epidemics to humans. Recently, Dudas et al. have done evolutionary analyses of reassortment patterns of the virus and suggested genetic lineage relationship between PB1, PB2, and HA genes. Using genetic plasmids and reassortant viruses, we here demonstrate that a homologous lineage PB1-PB2 pair exhibits better compatibility than a heterologous one and that the lineage relationship between PB1 and HA is more important for viral replication than that between PB2 and HA. However, co-adaptation of PB1-PB2-HA genes appears to be affected by complete gene constellation.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep27480