Central wave reflection is associated with peripheral arterial resistance in addition to arterial stiffness in subjects without antihypertensive medication

Augmentation index, a marker of central wave reflection, is influenced by age, sex, height, blood pressure, heart rate, and arterial stiffness. However, the detailed haemodynamic determinants of augmentation index, and their relations, remain uncertain. We examined the association of augmentation in...

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Bibliographic Details
Published in:BMC cardiovascular disorders 2016-06, Vol.16 (1), p.131-131, Article 131
Main Authors: Wilenius, Matias, Tikkakoski, Antti J, Tahvanainen, Anna M, Haring, Antti, Koskela, Jenni, Huhtala, Heini, Kähönen, Mika, Kööbi, Tiit, Mustonen, Jukka T, Pörsti, Ilkka H
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Aged
Aged, 80 and over
Analysis
Antihypertensive drugs
Arteries
Blood Pressure
Cardiography, Impedance
Clinical trials
Dosage and administration
Female
Heart beat
Heart Rate
Humans
Hypertension - diagnosis
Hypertension - physiopathology
Linear Models
Male
Manometry
Middle Aged
Models, Cardiovascular
Multivariate Analysis
Plethysmography, Whole Body
Predictive Value of Tests
Pulse Wave Analysis
Sex Distribution
Stenosis
Stroke Volume
Vascular Resistance
Vascular Stiffness
Young Adult
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Summary:Augmentation index, a marker of central wave reflection, is influenced by age, sex, height, blood pressure, heart rate, and arterial stiffness. However, the detailed haemodynamic determinants of augmentation index, and their relations, remain uncertain. We examined the association of augmentation index with vascular resistance and other haemodynamic and non-haemodynamic factors. Background information, laboratory values, and haemodynamics of 488 subjects (239 men, 249 women) without antihypertensive medication were obtained. Indices of central wave reflection, systemic vascular resistance, cardiac function, and pulse wave velocity were measured using continuous radial pulse wave analysis and whole-body impedance cardiography. In a regression model including only haemodynamic variables, augmentation index in males and female subjects, respectively, was associated with systemic vascular resistance (β = 0.425, β = 0.336), pulse wave velocity (β = 0.409, β = 0.400) (P 
ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-016-0303-6