Interleukin-6: an emerging regulator of pathological pain

Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been widely demonstrated that neuroinflammation plays a critical role in the development of pathological pain. Recently, various pathological pain models have shown elevated expression levels of interleukin-6 and...

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Bibliographic Details
Published in:Journal of neuroinflammation 2016-06, Vol.13 (1), p.141-141, Article 141
Main Authors: Zhou, Ya-Qun, Liu, Zheng, Liu, Zhi-Heng, Chen, Shu-Ping, Li, Man, Shahveranov, Allahverdi, Ye, Da-Wei, Tian, Yu-Ke
Format: Article
Language:English
Subjects:
Animals
Chemotherapy
Health aspects
Humans
Interleukin-6
Interleukin-6 - physiology
Interleukin-6 - toxicity
Pain
Pain - chemically induced
Pain - metabolism
Pain - pathology
Pain Measurement - drug effects
Pain Measurement - methods
Review
Risk factors
Signal Transduction - drug effects
Signal Transduction - physiology
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Summary:Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been widely demonstrated that neuroinflammation plays a critical role in the development of pathological pain. Recently, various pathological pain models have shown elevated expression levels of interleukin-6 and its receptor in the spinal cord and dorsal root ganglia. Additionally, the administration of interleukin-6 could cause mechanical allodynia and thermal hyperalgesia, and an intrathecal injection of anti-interleukin-6 neutralizing antibody alleviated these pain-related behaviors. These studies indicated a pivotal role of interleukin-6 in pathological pain. In this review, we summarize the recent progress in understanding the roles and mechanisms of interleukin-6 in mediating pathological pain associated with bone cancer, peripheral nerve injury, spinal cord injury, chemotherapy-induced peripheral neuropathy, complete Freund's adjuvant injection, and carrageenan injection. Understanding and regulating interleukin-6 could be an interesting lead to novel therapeutic strategies for pathological pain.
ISSN:1742-2094
1742-2094
DOI:10.1186/s12974-016-0607-6