Classical case of late-infantile form of metachromatic leukodystrophy

The MRI scan revealed confluent T2 and fluid-attenuated inversion recovery hyperintensities in the periventricular white matter and centrum semiovale with linear and dot-like hypointensities within it characteristic of the "tigroid" and "leopard skin" appearance of demyelination...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neurosciences in rural practice 2016-07, Vol.7 (3), p.473-475
Main Authors: Chauhan, Narvir, Sharma, Milap, Bhardwaj, Amit
Format: Article
Language:English
Subjects:
Attention deficit hyperactivity disorder
Conflicts of interest
Letters to the Editor
NMR
Nuclear magnetic resonance
Paralysis
Skin
Urine
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The MRI scan revealed confluent T2 and fluid-attenuated inversion recovery hyperintensities in the periventricular white matter and centrum semiovale with linear and dot-like hypointensities within it characteristic of the "tigroid" and "leopard skin" appearance of demyelination [Figure 1]a and [Figure 1]b. The posterior limb of internal capsule and the corpus callosum (genu, body, and splenium) were also involved [Figure 2] and [Figure 3]. [4] Diffusion-weighted MR imaging reveals restricted pattern of cytotoxic edema in the affected white matter in the absence of ischemia, the cause of which is probably due to restricted mobility of water molecules in the abnormal myelin.
ISSN:0976-3147
0976-3155
DOI:10.4103/0976-3147.181482