The mechanisms of Mallory–Denk body formation are similar to the formation of aggresomes in Alzheimer's disease and other neurodegenerative disorders

There is a possibility that the aggresomes that form in the brain in neurodegenerative diseases like Alzheimer's disease (AD) and in the liver where aggresomes like Mallory–Denk Bodies (MDB) form, share mechanisms. MDBs can be prevented by feeding mice sadenosylmethionine (SAMe) or betaine. Pos...

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Bibliographic Details
Published in:Experimental and molecular pathology 2016-06, Vol.100 (3), p.426-433
Main Authors: French, S.W., Mendoza, A.S., Peng, Y.
Format: Article
Language:English
Subjects:
26S proteasome
Alzheimer Disease - metabolism
Animals
Autophagosomes - metabolism
Humans
Mallory Bodies - metabolism
Models, Biological
Neurodegenerative Diseases - metabolism
Neurofibrillary tangles (NFT)
Proteasome Endopeptidase Complex - metabolism
Protein Aggregates
Protein Aggregation, Pathological - metabolism
Protein quality control
β amyloid (Aβ)
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Summary:There is a possibility that the aggresomes that form in the brain in neurodegenerative diseases like Alzheimer's disease (AD) and in the liver where aggresomes like Mallory–Denk Bodies (MDB) form, share mechanisms. MDBs can be prevented by feeding mice sadenosylmethionine (SAMe) or betaine. Possibly these proteins could prevent AD. We compared the literature on MDBs and AD pathogenesis, which include roles played by p62, ubiquitin UBB +1, HSPs70, 90, 104, FAT10, NEDD8, VCP/97, and the protein quality control mechanisms including the 26s proteasome, the IPOD and JUNQ and autophagosome pathways.
ISSN:0014-4800
1096-0945
DOI:10.1016/j.yexmp.2016.03.010