Potential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity

Manganese is a vital nutrient and is maintained at an optimal level (2.5–5 mg/day) in human body. Chronic exposure to manganese is associated with neurotoxicity and correlated with the development of various neurological disorders such as Parkinson’s disease. Oxidative stress mediated apoptotic cell...

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Bibliographic Details
Published in:BioMed research international 2016-01, Vol.2016 (2016), p.1-18
Main Authors: Bafana, Amit, Naoghare, Pravin K., Sivanesan, Saravanadevi, Chakrabarti, Tapan, Tarale, Prashant, Kannan, Krishnamurthi
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Binding sites
Brain research
Development and progression
DNA methylation
Drinking water
Epigenesis, Genetic - drug effects
Epigenetic inheritance
Epigenetics
Gene expression
Globus Pallidus - drug effects
Humans
Hypotheses
Iron
Manganese - toxicity
Mice
Nervous system
Nervous system diseases
Neurons
Neurotoxicity
Neurotoxicity Syndromes
Neurotoxins - toxicity
Oxidative stress
Oxidative Stress - drug effects
Parkinson's disease
Pesticides
Population
Rats
Review
Rodents
Signal Transduction - drug effects
Studies
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Summary:Manganese is a vital nutrient and is maintained at an optimal level (2.5–5 mg/day) in human body. Chronic exposure to manganese is associated with neurotoxicity and correlated with the development of various neurological disorders such as Parkinson’s disease. Oxidative stress mediated apoptotic cell death has been well established mechanism in manganese induced toxicity. Oxidative stress has a potential to alter the epigenetic mechanism of gene regulation. Epigenetic insight of manganese neurotoxicity in context of its correlation with the development of parkinsonism is poorly understood. Parkinson’s disease is characterized by the α-synuclein aggregation in the form of Lewy bodies in neuronal cells. Recent findings illustrate that manganese can cause overexpression of α-synuclein. α-Synuclein acts epigenetically via interaction with histone proteins in regulating apoptosis. α-Synuclein also causes global DNA hypomethylation through sequestration of DNA methyltransferase in cytoplasm. An individual genetic difference may also have an influence on epigenetic susceptibility to manganese neurotoxicity and the development of Parkinson’s disease. This review presents the current state of findings in relation to role of epigenetic mechanism in manganese induced neurotoxicity, with a special emphasis on the development of Parkinson’s disease.
ISSN:2314-6133
2314-6141
DOI:10.1155/2016/2548792