Sensitization to the locomotor stimulant effects of “bath salt” constituents, 4‐methylmethcathinone (4-MMC) and 3,4-methylenedioxypyrovalerone (MDPV), in male Sprague-Dawley rats

Highlights • Locomotor activity sensitized to MDPV and to low dose mixtures of 4-MMC and MDPV. • Cross‐sensitization to cocaine was evident following exposure to MDPV and 4-MMC. • Studies on the abuse liability of synthetic cathinone mixtures may be warranted.

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Bibliographic Details
Published in:Drug and alcohol dependence 2016-07, Vol.164, p.128-134
Main Authors: Berquist, Michael D, Traxler, Haily K, Mahler, Alyssa M, Baker, Lisa E
Format: Article
Language:English
Subjects:
3,4
4-Methylmethcathinone
4-MMC
Animals
Bath salts
Benzodioxoles - toxicity
Central Nervous System Stimulants - toxicity
Cocaine
Cocaine - toxicity
Cross-sensitization
Dose-Response Relationship, Drug
Drug Interactions
Locomotion - drug effects
Locomotor sensitization
Male
MDPV
Mephedrone
Methamphetamine - analogs & derivatives
Methamphetamine - toxicity
Methylenedioxypyrovalerone
Psychiatry
Pyrrolidines - toxicity
Rats
Rats, Sprague-Dawley
Synthetic cathinones
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Description
Summary:Highlights • Locomotor activity sensitized to MDPV and to low dose mixtures of 4-MMC and MDPV. • Cross‐sensitization to cocaine was evident following exposure to MDPV and 4-MMC. • Studies on the abuse liability of synthetic cathinone mixtures may be warranted.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2016.05.001