Independent and Co-morbid HIV Infection and Meth Use Disorders on Oxidative Stress Markers in the Cerebrospinal Fluid and Depressive Symptoms

Both HIV infection and Methamphetamine (Meth) use disorders are associated with greater depressive symptoms and oxidative stress; whether the two conditions would show additive or interactive effects on the severity of depressive symptoms, and whether this is related to the level of oxidative stress...

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Bibliographic Details
Published in:Journal of neuroimmune pharmacology 2015-03, Vol.10 (1), p.111-121
Main Authors: Panee, Jun, Pang, Xiaosha, Munsaka, Sody, Berry, Marla J., Chang, Linda
Format: Article
Language:English
Subjects:
Aging - metabolism
Amphetamine-Related Disorders - cerebrospinal fluid
Amphetamine-Related Disorders - complications
Amphetamine-Related Disorders - psychology
Biomarkers - cerebrospinal fluid
Biomedical and Life Sciences
Biomedicine
Cell Biology
Dementia - etiology
Dementia - psychology
Depression - psychology
Drug use
Female
HIV
HIV Infections - cerebrospinal fluid
HIV Infections - complications
HIV Infections - psychology
Human immunodeficiency virus
Humans
Immunology
Male
Methamphetamine
Middle Aged
Neurosciences
Original Article
Oxidation
Oxidative stress
Oxidative Stress - drug effects
Pharmacology/Toxicology
Psychiatric Status Rating Scales
Virology
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Summary:Both HIV infection and Methamphetamine (Meth) use disorders are associated with greater depressive symptoms and oxidative stress; whether the two conditions would show additive or interactive effects on the severity of depressive symptoms, and whether this is related to the level of oxidative stress in the CNS is unknown. 123 participants were evaluated, which included 41 HIV-seronegative subjects without substance use disorders (Control), 25 with recent (
ISSN:1557-1890
1557-1904
DOI:10.1007/s11481-014-9581-x