Evaluating the Minimal Specimens From Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Pancreatic Masses

Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has become one of the most useful diagnostic modalities for the diagnosis of pancreatic mass. The aim of this study was to investigate the role of analyzing the minimal specimens obtained by EUS-FNA for the diagnosis of solid masses of pa...

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Bibliographic Details
Published in:Medicine (Baltimore) 2016-05, Vol.95 (21), p.e3740-e3740
Main Authors: Park, Joo Kyung, Kang, Ki Joo, Oh, Cho Rong, Lee, Jong Kyun, Lee, Kyu Taek, Jang, Kee Taek, Park, Sang-Mo, Lee, Kwang Hyuck
Format: Article
Language:English
Subjects:
Aged
Endoscopic Ultrasound-Guided Fine Needle Aspiration - methods
Female
Humans
Immunohistochemistry
Male
Middle Aged
Observational Study
Pancreatic Diseases - diagnosis
Pancreatic Diseases - pathology
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - pathology
Prospective Studies
Retrospective Studies
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Summary:Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has become one of the most useful diagnostic modalities for the diagnosis of pancreatic mass. The aim of this study was to investigate the role of analyzing the minimal specimens obtained by EUS-FNA for the diagnosis of solid masses of pancreas.This study consisted of retrospective and prospective analyses. The retrospective study was performed on 116 patients who underwent EUS-FNA of solid masses for cytological smear, histological analysis, and combined analysis including immunohistochemical (IHC) staining. In the prospective study, 79 patients were enrolled to evaluate the quality and accuracy of EUS-FNA histological analysis and feasibility of IHC staining.The final diagnoses of all patients included pancreatic cancer (n = 126), nonpancreatic cancer (n = 21), other neoplasm (n = 27), and benign lesions (n = 21). In our retrospective study, the combined analysis was more sensitive than cytological analysis alone (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000003740