Melatonin influence in ovary transplantation: systematic review

Melatonin is an indolamine produced by the pineal gland and it can exert a potent antioxidant effect. Its free radical scavenger properties have been used to advantage in different organ transplants in animal experiments. Several concentrations and administration pathways have been tested and melato...

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Bibliographic Details
Published in:Journal of ovarian research 2016-06, Vol.9 (1), p.33, Article 33
Main Authors: Shiroma, M E, Botelho, N M, Damous, L L, Baracat, E C, Soares, Jr, J M
Format: Article
Language:English
Subjects:
Analysis
Animals
Antioxidants - metabolism
Antioxidants - pharmacology
Apoptosis - drug effects
Female
Graft Survival - drug effects
Health aspects
Humans
Melatonin
Melatonin - metabolism
Melatonin - pharmacology
Neovascularization, Physiologic - drug effects
Organ Transplantation
Ovaries
Ovary - drug effects
Ovary - metabolism
Ovary - transplantation
Oxidative Stress - drug effects
Review
Transplantation
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Summary:Melatonin is an indolamine produced by the pineal gland and it can exert a potent antioxidant effect. Its free radical scavenger properties have been used to advantage in different organ transplants in animal experiments. Several concentrations and administration pathways have been tested and melatonin has shown encouraging beneficial results in many transplants of organs such as the liver, lungs, heart, pancreas, and kidneys. The objective of the present study was to review the scientific literature regarding the use of melatonin in ovary transplantation. A systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was carried out using the Cochrane and Pubmed databases and employing the terms 'melatonin' AND 'ovary' AND 'transplantation.' After analysis, 5 articles were extracted addressing melatonin use in ovary transplants and involving 503 animals. Melatonin enhanced various graft aspects like morphology, apoptosis, immunological reaction, revascularization, oxidative stress, and survival rate. Melatonin's antioxidative and antiapoptotic properties seemingly produce positive effects on ovarian graft activity. Despite the promising results, further studies in humans need to be conducted to consolidate its use, as ovary transplantation for fertility preservation is gradually being moved from the experimental stage to a clinical setting.
ISSN:1757-2215
1757-2215
DOI:10.1186/s13048-016-0245-8