Flexible Octopus-Shaped Hydrogel Particles for Specific Cell Capture

Multiarm hydrogel microparticles with varying geometry are fabricated to specifically capture cells expressing epithelial cell adhesion molecule. Results show that particle shape influences cell‐capture efficiency due to differences in surface area, hydrodynamic effects, and steric constraints. Thes...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2016-04, Vol.12 (15), p.2001-2008
Main Authors: Chen, Lynna, An, Harry Z., Haghgooie, Ramin, Shank, Aaron T., Martel, Joseph M., Toner, Mehmet, Doyle, Patrick S.
Format: Article
Language:English
Subjects:
Antibodies - metabolism
Atoms & subatomic particles
Cell adhesion
Cell adhesion & migration
cell capture
Cell Line, Tumor
Cell Separation - methods
circulating tumor cells
Design improvements
Fluid dynamics
Fluid flow
Humans
Hydrodynamics
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
Hydrogels
Microfluidics
Microparticles
Nanotechnology
Surface area
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Description
Summary:Multiarm hydrogel microparticles with varying geometry are fabricated to specifically capture cells expressing epithelial cell adhesion molecule. Results show that particle shape influences cell‐capture efficiency due to differences in surface area, hydrodynamic effects, and steric constraints. These findings can lead to improved particle design for cell separation and diagnostic applications.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201600163