BRCA1: a movement toward cancer prevention

Breast cancer susceptibility gene 1 (BRCA1) was first identified in 1994 and has since been shown to encode a tumor suppressor protein that maintains genetic stability through DNA damage response pathways. Carriers of mutations in BRCA1 are predisposed to breast and ovarian cancer; however, their ca...

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Bibliographic Details
Published in:Molecular & cellular oncology 2015-07, Vol.2 (3), p.e979685-e979685
Main Authors: Alli, Elizabeth, Ford, James M
Format: Article
Language:English
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base-excision DNA repair
BRCA1
breast cancer
chemoprevention
oxidative DNA damage
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Summary:Breast cancer susceptibility gene 1 (BRCA1) was first identified in 1994 and has since been shown to encode a tumor suppressor protein that maintains genetic stability through DNA damage response pathways. Carriers of mutations in BRCA1 are predisposed to breast and ovarian cancer; however, their cancers lack the targets for existing anticancer drugs. We describe a novel chemoprevention approach that uses DNA repair-activating agents to enhance the repair of oxidative DNA damage and, in turn, prevent tumorigenesis in the presence of mutant BRCA1.
ISSN:2372-3556
2372-3548
2372-3556
DOI:10.4161/23723556.2014.979685