TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling

In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subse...

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Published in:Molecular & cellular oncology 2015-07, Vol.2 (3), p.e980134-e980134
Main Authors: Salazar, María, Lorente, Mar, García-Taboada, Elena, Gómez, Eduardo Pérez, Dávila, David, Zúñiga-García, Patricia, Flores, Juana M, Rodríguez, Antonio, Hegedus, Zoltan, Mosén-Ansorena, David, Aransay, Ana M, Hernández-Tiedra, Sonia, López-Valero, Israel, Quintanilla, Miguel, Sánchez, Cristina, Iovanna, Juan L, Dusetti, Nelson, Guzmán, Manuel, Francis, Sheila E, Carracedo, Arkaitz, Kiss-Toth, Endre, Velasco, Guillermo
Format: Article
Language:English
Subjects:
animal models of cancer
Author's Views
prostate cancer
PTEN
skin carcinogenesis
Tribbles pseudokinases
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Summary:In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).
ISSN:2372-3556
2372-3548
2372-3556
DOI:10.4161/23723556.2014.980134