A double blind study of metoclopramide in the treatment of migraine attacks

One hundred and fifty patients with migraine attacks attending the Copenhagen acute migraine clinic were treated either with metoclopramide 10 mg i.m. metoclopramide 20 mg as suppository or placebo in a double blind trial. All patients simultaneously or 30 minutes later received paracetamol 1 g and...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1980-04, Vol.43 (4), p.369-371
Main Authors: Tfelt-Hansen, P, Olesen, J, Aebelholt-Krabbe, A, Melgaard, B, Veilis, B
Format: Article
Language:English
Subjects:
Acetaminophen - therapeutic use
Adolescent
Adult
Aged
Diazepam - therapeutic use
Double-Blind Method
Drug Therapy, Combination
Female
Humans
Male
Metoclopramide - therapeutic use
Middle Aged
Migraine Disorders - drug therapy
Nausea - drug therapy
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Summary:One hundred and fifty patients with migraine attacks attending the Copenhagen acute migraine clinic were treated either with metoclopramide 10 mg i.m. metoclopramide 20 mg as suppository or placebo in a double blind trial. All patients simultaneously or 30 minutes later received paracetamol 1 g and diazepam 5 mg orally. The nausea was relieved in 71% of the patients by placebo and bed rest, but metoclopramide was significantly (p = 0.04) more effective and relieved nausea in 86% of the patients. Metoclopramide did not by itself reduce the pain, but enhanced the effect of the analgesic or sedative medication. This effect, however, just failed to be statistically significant (p = 0.06).
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.43.4.369