Expression and clinical significance of glucose transporter-1 in pancreatic cancer

Increasing evidence has demonstrated that malignant cells exhibit increased glucose uptake, which facilitates survival and growth in a hypoxic environment. The glucose transporter-1 (GLUT-1) is overexpressed in a variety of malignant tumors. However, the association between GLUT-1 expression and cli...

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Bibliographic Details
Published in:Oncology letters 2016-07, Vol.12 (1), p.243-249
Main Authors: LU, KAI, YANG, JIAN, LI, DE-CHUN, HE, SONG-BING, ZHU, DONG-MING, ZHANG, LI-FENG, ZHANG, XU, CHEN, XIAO-CHEN, ZHANG, BING, ZHOU, JIAN
Format: Article
Language:English
Subjects:
18F-fluorodeoxyglucose
Breast cancer
Carrier proteins
Cell cycle
Clinical significance
Development and progression
Gender
Gene expression
Genetic aspects
Glucose
glucose transporter-1
Health aspects
Hypoxia
Innovations
Ki-67
Lymphatic system
Medical prognosis
Metastasis
Molecular targeted therapy
Multivariate analysis
Oncology
Pancreatic cancer
Patients
Prognosis
Properties
Tumors
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Summary:Increasing evidence has demonstrated that malignant cells exhibit increased glucose uptake, which facilitates survival and growth in a hypoxic environment. The glucose transporter-1 (GLUT-1) is overexpressed in a variety of malignant tumors. However, the association between GLUT-1 expression and clinicopathological factors, 18F-fluorodeoxyglucose uptake and tumor proliferation in pancreatic cancer has not been investigated to date. In the present study, the expression of GLUT-1 in 53 pancreatic cancer tissues was analyzed, which revealed that GLUT-1 was overexpressed in pancreatic tissue and correlated with poor prognosis and clinicopathological characteristics, including increased tumor size, clinical stage and lymph node metastasis, maximum standardized uptake value (SUVmax) and Ki-67 expression. The receiver operating characteristic curve analysis indicated that a cut-off SUVmax value of 4.830 was associated with optimal sensitivity (88%) and specificity (71.4%) for the detection of strong positive GLUT-1 expression. In addition, as the expression of GLUT-1 was found to correlate with Ki-67 expression, GLUT-1 may exhibit a significant effect on cell proliferation in pancreatic cancer. Overall, these findings indicate that GLUT-1 may represent a prognostic indicator, and a potential therapeutic target for pancreatic cancer.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2016.4586