Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A case report

Mixed adenoneuroendocrine carcinomas (MANECs) are rare biphasic tumour types, which are morphologically recognisable as both gland-forming and neuroendocrine neoplasms. Within the gastrointestinal tract, MANECs occur predominantly in the stomach or colorectum. The present study described a case of a...

Full description

Saved in:
Bibliographic Details
Published in:Molecular and clinical oncology 2016-07, Vol.5 (1), p.95-98
Main Authors: MAX, NICOLE, ROTHE, ALEXANDER, LANGNER, CORD
Format: Article
Language:English
Subjects:
adenocarcinoma
Care and treatment
Case reports
Case studies
chemotherapy
Diagnosis
Histology
immunohistochemistry
Liver cancer
Medical prognosis
Metastasis
mixed adenoneuroendocrine carcinoma
mixed tumour
neuroendocrine carcinoma
Oncology
Pancreatic cancer
Patients
Tumors
tumour heterogeneity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mixed adenoneuroendocrine carcinomas (MANECs) are rare biphasic tumour types, which are morphologically recognisable as both gland-forming and neuroendocrine neoplasms. Within the gastrointestinal tract, MANECs occur predominantly in the stomach or colorectum. The present study described a case of a MANEC originating from the ampullary region. The patient presented with widespread metastatic disease. Biopsy samples obtained from the ampullary primary tumour disclosed a complex lesion with adenocarcinoma and neuroendocrine small cell carcinoma components, positive for the intestinal transcription factor caudal type homeobox-2 and for neuroendocrine markers, including chromogranin A, synaptophysin, cluster of differentiation 56/neural cell adhesion molecule. By contrast, biopsy samples obtained from metastatic tissue revealed pure neuroendocrine carcinoma. As exemplified by this true mixed tumour, tumour heterogeneity evolves as the major challenge in oncology today, with potentially severe implications for the choice of chemotherapy. The assessment of metastatic sites may render valuable diagnostic information that is crucial for clinical decision-making and patient management.
ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2016.858