Detection of cancer embryo antigen and endothelin-1 in exhaled breath condensate: A novel approach to investigate non-small cell lung cancer

• Published in: Molecular and clinical oncology 2016-07, Vol.5 (1), p.124-128
• Main Authors: CHEN, JIN-LIANG, LV, XUE-DONG, MA, HANG, CHEN, JIAN-RONG, HUANG, JIAN-AN
• Format: Article
• Language: English
• Subjects: Antigens; Biomarkers; Breath tests; cancer embryo antigen; Diagnosis; Endothelin; endothelin-1; exhaled breath condensate; Genetic aspects; Identification and classification; Innovations; Lung cancer; Lung cancer, Non-small cell; Medical prognosis; Metastasis; Mortality; non-small cell lung cancer; Normal distribution; Oncology; Researchers; Studies; Thoracic surgery; Tumor antigens
• ISSN: 2049-9450; 2049-9469
• DOI: 10.3892/mco.2016.902

The present study aimed to investigate the clinical significance of cancer embryo antigen (CEA) and endothelin-1 (ET-1) in the exhaled breath condensate (EBC) of patients with non-small cell lung cancer (NSCLC). EBC samples were collected from 143 patients with NSCLC and 119 healthy individuals by using an EBC collector. The CEA and ET-1 levels in the EBC and serum were detected. The levels of CEA and ET-1 in the serum and EBC of the NSCLC group were higher compared with those of the healthy group. The level of CEA in the EBC of the adenocarcinoma group was higher compared with that in the squamous cell carcinoma group. The levels of CEA and ET-1 in the serum and EBC in stages III and IV were higher compared with those in stages I and II. The levels of CEA and ET-1 in the EBC were positively correlated with those in the serum, and furthermore, they exhibited high specificity and sensitivity. Thus, these parameters may be used to diagnose lung cancer. The detection of CEA and ET-1 in EBC may help the process of diagnosing and monitoring the progression of NSCLC.