Association of EVI5 rs11808092, CD58 rs2300747, and CIITA rs3087456 polymorphisms with multiple sclerosis risk: A meta-analysis

Multiple sclerosis (MS) is a major demyelinating disease of the central nervous system with a strong genetic component. Previous studies have reported that the association of EVI5 rs11808092, CD58 rs2300747, and CIITA rs3087456 polymorphisms with the susceptibility to MS. However, the results were i...

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Bibliographic Details
Published in:Meta Gene 2016-09, Vol.9, p.97-103
Main Authors: Liu, Jiahe, Liu, Xu, Liu, Yong, Deng, Shimin, Huang, Hongbin, Chen, Qicong, Liu, Weidong, Huang, Zunnan
Format: Article
Language:English
Subjects:
CD58 rs2300747
CIITA rs3087456
EVI5 rs11808092
Meta-analysis
Multiple sclerosis
Polymorphisms
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Summary:Multiple sclerosis (MS) is a major demyelinating disease of the central nervous system with a strong genetic component. Previous studies have reported that the association of EVI5 rs11808092, CD58 rs2300747, and CIITA rs3087456 polymorphisms with the susceptibility to MS. However, the results were inconsistent. Thus, we conducted this meta-analysis to provide a more accurate estimation of the association between any of these polymorphisms and MS risk. The PubMed, Embase, Chinese National Knowledge Infrastructure, Wan Fang databases and MSGene were used to search all potentially relevant studies. The odds ratio (OR) with 95% confidence interval (CI) was used to investigate the associations between these three polymorphisms and MS risk. 16 independent case–control studies from 12 publications were finally included into this meta-analysis. The results showed that EVI5 rs11808092 polymorphism was related with increasing the development of MS under five genetic models (allelic: OR=1.17, 95% CI=1.10–1.24, P
ISSN:2214-5400
2214-5400
DOI:10.1016/j.mgene.2016.04.005