Genetic polymorphisms of interleukin 1β gene and sporadic pancreatic neuroendocrine tumors susceptibility

AIM.:To evaluate the association between the interleukin 1β(IL-1β) polymorphisms and the pancreatic neuroendocrine tumor(pN ET) development.METHODS.:A case-control study was conducted analyzing IL-1β polymorphisms using germline DNA collected in a population-based case-control study of pancreatic ca...

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Bibliographic Details
Published in:World journal of gastrointestinal oncology 2016-06, Vol.8 (6), p.520-525
Main Authors: Karakaxas, Dimitrios, Sioziou, Anna, Aravantinos, Gerasimos, Coker, Ahmet, Papanikolaou, Ioannis S, Liakakos, Theodoros, Dervenis, Christos, Gazouli, Maria
Format: Article
Language:English
Subjects:
1β
Neuroendocrine
Case Control Study
Interleukin
tumors
Pancreas
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Summary:AIM.:To evaluate the association between the interleukin 1β(IL-1β) polymorphisms and the pancreatic neuroendocrine tumor(pN ET) development.METHODS.:A case-control study was conducted analyzing IL-1β polymorphisms using germline DNA collected in a population-based case-control study of pancreatic cancer(51 pN ET cases,85 pancreatic ductal adenocarcinoma cases,19 intraductal papillary mucinous neoplasm and 98 healthy controls).RESULTS.:The distribution of genotypes for the-511C/T polymorphism in the pN ET patient groups showed significant difference compared to the control group.It is known that the carriers of the IL-1β-511 T allele have increased concentrations of IL-1β.The-511 CT and TT high-expression genotypes were over-represented in pN ET patients.CONCLUSION.:The findings of this study suggested a possible role of IL-1β-511 C/T genotypes in the pathogenesis of pN ETs since the presence of the IL-1β-511 CT and TT genotypes and the T allele was associated with an increased risk of pN ET only.
ISSN:1948-5204
1948-5204
DOI:10.4251/wjgo.v8.i6.520