Facile and scalable disposable sensor based on laser engraved graphene for electrochemical detection of glucose

• Published in: Scientific reports 2016-06, Vol.6 (1), p.27975-27975, Article 27975
• Main Authors: Tehrani, Farshad, Bavarian, Behzad
• Format: Article
• Language: English
• Subjects: 631/61/350/59; 631/61/54/990; 639/166/985; 639/925/918; 96/10; Biosensors; Body Fluids - chemistry; Carbon; Chemical vapor deposition; Chemistry Techniques, Analytical - instrumentation; Chemistry Techniques, Analytical - methods; Copper; Diabetes; Electrochemical Techniques - instrumentation; Electrochemical Techniques - methods; Electrochemistry; Electrodes; Engraving; Enzymes; Fabrication; Glucose; Glucose - analysis; Graphene; Graphite; Humanities and Social Sciences; Lasers; Manufacturing; multidisciplinary; Nanoparticles; Reproducibility of Results; Science; Science (multidisciplinary); Sensitivity and Specificity; Sensors; Spectrum analysis; Systems engineering
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep27975

A novel and highly sensitive disposable glucose sensor strip was developed using direct laser engraved graphene (DLEG) decorated with pulse deposited copper nanocubes (CuNCs). The high reproducibility (96.8%), stability (97.4%) and low cost demonstrated by this 3-step fabrication method indicates that it could be used for high volume manufacturing of disposable glucose strips. The fabrication method also allows for a high degree of flexibility, allowing for control of the electrode size, design, and functionalization method. Additionally, the excellent selectivity and sensitivity (4,532.2 μA/mM.cm 2 ), low detection limit (250 nM), and suitable linear range of 25 μM–4 mM, suggests that these sensors may be a great potential platform for glucose detection within the physiological range for tear, saliva, and/or sweat.