Fatal canine distemper virus infection of giant pandas in China

We report an outbreak of canine distemper virus (CDV) infection among endangered giant pandas ( Ailuropoda melanoleuca ). Five of six CDV infected giant pandas died. The surviving giant panda was previously vaccinated against CDV. Genomic sequencing of CDV isolated from one of the infected pandas (g...

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Bibliographic Details
Published in:Scientific reports 2016-06, Vol.6 (1), p.27518-27518, Article 27518
Main Authors: Feng, Na, Yu, Yicong, Wang, Tiecheng, Wilker, Peter, Wang, Jianzhong, Li, Yuanguo, Sun, Zhe, Gao, Yuwei, Xia, Xianzhu
Format: Article
Language:English
Subjects:
13/106
45/23
45/77
631/326/421
631/326/596/2562
631/326/596/2563
Animals
Antibodies
Binding Sites - genetics
Brain research
China - epidemiology
Death & dying
Distemper - epidemiology
Distemper - virology
Distemper Virus, Canine - genetics
Distemper Virus, Canine - pathogenicity
Dogs
Endangered & extinct species
Endangered species
Epidemics
Hemagglutinins - genetics
Humanities and Social Sciences
Infections
Lungs
multidisciplinary
Pandas
Pneumonia
Research centers
Science
Science (multidisciplinary)
Signaling Lymphocytic Activation Molecule Family - genetics
Ursidae - virology
Vaccination - methods
Viruses
Wildlife conservation
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Summary:We report an outbreak of canine distemper virus (CDV) infection among endangered giant pandas ( Ailuropoda melanoleuca ). Five of six CDV infected giant pandas died. The surviving giant panda was previously vaccinated against CDV. Genomic sequencing of CDV isolated from one of the infected pandas (giant panda/SX/2014) suggests it belongs to the Asia-1 cluster. The hemagglutinin protein of the isolated virus and virus sequenced from lung samples originating from deceased giant pandas all possessed the substitutions V26M, T213A, K281R, S300N, P340Q, and Y549H. The presence of the Y549H substitution is notable as it is found at the signaling lymphocytic activation molecule (SLAM) receptor-binding site and has been implicated in the emergence of highly pathogenic CDV and host switching. These findings demonstrate that giant pandas are susceptible to CDV and suggest that surveillance and vaccination among all captive giant pandas are warranted to support conservation efforts for this endangered species.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep27518