The role of cytokines in the pathophysiology of suicidal behavior

Highlights • We reviewed 22 articles concerning cytokines and suicidal ideation, suicide attempts or suicide completion. • The most consistent finding was elevated interleukin (IL)-6, found in 8 out of 14 studies, in CSF, blood, and postmortem brain, and associated with more violent attempts and fut...

Full description

Saved in:
Bibliographic Details
Published in:Psychoneuroendocrinology 2016-01, Vol.63, p.296-310
Main Authors: Ganança, Licínia, Oquendo, Maria A, Tyrka, Audrey R, Cisneros-Trujillo, Sebastian, Mann, J. John, Sublette, M. Elizabeth
Format: Article
Language:English
Subjects:
Cytokines - blood
Depression - blood
Depression - epidemiology
Depression - psychology
Endocrinology & Metabolism
Humans
Inflammation - blood
Inflammation - epidemiology
Inflammation - psychology
Inflammation Mediators - blood
Psychiatry
Self-Injurious Behavior - blood
Self-Injurious Behavior - epidemiology
Self-Injurious Behavior - psychology
Suicidal Ideation
Suicide - psychology
Suicide - statistics & numerical data
Suicide, Attempted - psychology
Suicide, Attempted - statistics & numerical data
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • We reviewed 22 articles concerning cytokines and suicidal ideation, suicide attempts or suicide completion. • The most consistent finding was elevated interleukin (IL)-6, found in 8 out of 14 studies, in CSF, blood, and postmortem brain, and associated with more violent attempts and future suicide completion. • Considerable heterogeneity among cytokine results indicates a high level of complexity. • Thus putative mediators and moderators of the effects of inflammation on suicide risk merit further study.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2015.10.008