Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice

Somatostatin (SST)-positive interneurons in the anterior cingulate cortex (ACC) play important roles in neuronal diseases, memory and cognitive functions. However, their development in the ACC remains unclear. Using postnatal day 3 (P3) to P45 GIN mice, we found that most of the intrinsic membrane p...

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Bibliographic Details
Published in:Scientific reports 2016-06, Vol.6 (1), p.28137-28137, Article 28137
Main Authors: Pan, Geng, Yang, Jian-Ming, Hu, Xing-Yue, Li, Xiao-Ming
Format: Article
Language:English
Subjects:
14/19
14/35
14/63
631/378/2571/1696
631/378/2591
9/74
Action Potentials - physiology
Animals
Cognitive ability
Electrophysiological Phenomena - physiology
Environmental regulations
Epilepsy
Eye - innervation
Female
Green Fluorescent Proteins - genetics
Gyrus Cinguli - embryology
Humanities and Social Sciences
Interneurons - cytology
Male
Mice
Mice, Transgenic
multidisciplinary
Neurobiology
Neurosciences
Science
Somatostatin - metabolism
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Summary:Somatostatin (SST)-positive interneurons in the anterior cingulate cortex (ACC) play important roles in neuronal diseases, memory and cognitive functions. However, their development in the ACC remains unclear. Using postnatal day 3 (P3) to P45 GIN mice, we found that most of the intrinsic membrane properties of SST interneurons in the ACC were developmentally mature after the second postnatal week and that the development of these neurons differed from that of parvalbumin (PV) interneurons in the prefrontal cortex. In addition, electrical coupling between SST interneurons appeared primarily between P12–14. The coupling probability plateaued at approximately P21–30, with a non-age-dependent development of coupling strength. The development of excitatory chemical afferents to SST interneurons occurred earlier than the development of inhibitory chemical afferents. Furthermore, eye closure attenuated the development of electrical coupling probability at P21–30 but had no effect on coupling strength. Eye closure also delayed the development of inhibitory chemical afferent frequency but had no effect on the excitatory chemical afferent amplitude, frequency or rise time. Our data suggest that SST interneurons in the ACC exhibit inherent developmental characteristics distinct from other interneuron subtypes, such as PV interneurons and that some of these characteristics are subject to environmental regulation.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep28137