Replication origins: determinants or consequences of nuclear organization?

Chromosome replication, gene expression and chromatin assembly all occur on the same template, necessitating a tight spatial and temporal coordination to maintain genomic stability. The distribution of replication initiation events is responsive to local and global changes in chromatin structure and...

Full description

Saved in:
Bibliographic Details
Published in:Current opinion in genetics & development 2016-04, Vol.37, p.67-75
Main Authors: Marks, Anna B, Smith, Owen K, Aladjem, Mirit I
Format: Article
Language:English
Subjects:
Chromatin - genetics
Chromatin Assembly and Disassembly - genetics
DNA Replication - genetics
Genomic Instability
Humans
Medical Education
Replication Origin - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chromosome replication, gene expression and chromatin assembly all occur on the same template, necessitating a tight spatial and temporal coordination to maintain genomic stability. The distribution of replication initiation events is responsive to local and global changes in chromatin structure and is affected by transcriptional activity. Concomitantly, replication origin sequences, which determine the locations of replication initiation events, can affect chromatin structure and modulate transcriptional efficiency. The flexibility observed in the replication initiation landscape might help achieve complete and accurate genome duplication while coordinating the DNA replication program with transcription and other nuclear processes in a cell-type specific manner. This review discusses the relationships among replication origin distribution, local and global chromatin structures and concomitant nuclear metabolic processes.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2015.11.008