Evolutionary Turnover of Kinetochore Proteins: A Ship of Theseus?

The kinetochore is a multiprotein complex that mediates the attachment of a eukaryotic chromosome to the mitotic spindle. The protein composition of kinetochores is similar across species as divergent as yeast and human. However, recent findings have revealed an unexpected degree of compositional di...

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Bibliographic Details
Published in:Trends in cell biology 2016-07, Vol.26 (7), p.498-510
Main Authors: Drinnenberg, Ines A, Henikoff, Steven, Malik, Harmit S
Format: Article
Language:English
Subjects:
Animals
CenH3
CENP-B
CENP-T
Chromosomal Proteins, Non-Histone - metabolism
Chromosome Segregation
Eukaryotic Cells - metabolism
Evolution, Molecular
evolutionary dynamics
functional conservation
Humans
kinetochore
Kinetochores - metabolism
Models, Biological
Pathology
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Summary:The kinetochore is a multiprotein complex that mediates the attachment of a eukaryotic chromosome to the mitotic spindle. The protein composition of kinetochores is similar across species as divergent as yeast and human. However, recent findings have revealed an unexpected degree of compositional diversity in kinetochores. For example, kinetochore proteins that are essential in some species have been lost in others, whereas new kinetochore proteins have emerged in other lineages. Even in lineages with similar kinetochore composition, individual kinetochore proteins have functionally diverged to acquire either essential or redundant roles. Thus, despite functional conservation, the repertoire of kinetochore proteins has undergone recurrent evolutionary turnover.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2016.01.005