Comparative In Vitro Activities of Oritavancin, Dalbavancin, and Vancomycin against Methicillin-Resistant Staphylococcus aureus Isolates in a Nondividing State

Antibacterial agents that kill nondividing bacteria may be of utility in treating persistent infections. Oritavancin and dalbavancin are bactericidal lipoglycopeptides that are approved for acute bacterial skin and skin structure infections in adults caused by susceptible Gram-positive pathogens. Us...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2016-07, Vol.60 (7), p.4342-4345
Main Authors: Belley, Adam, Lalonde Seguin, David, Arhin, Francis, Moeck, Greg
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacology
Glycopeptides
Glycopeptides - pharmacology
Methicillin-Resistant Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus - drug effects
Microbial Sensitivity Tests
Pharmacology
Staphylococcus aureus
Teicoplanin
Teicoplanin - analogs & derivatives
Teicoplanin - pharmacology
Vancomycin
Vancomycin - pharmacology
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Summary:Antibacterial agents that kill nondividing bacteria may be of utility in treating persistent infections. Oritavancin and dalbavancin are bactericidal lipoglycopeptides that are approved for acute bacterial skin and skin structure infections in adults caused by susceptible Gram-positive pathogens. Using time-kill methodology, we demonstrate that oritavancin exerts bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA) isolates that are maintained in a nondividing state in vitro, whereas dalbavancin and the glycopeptide vancomycin do not.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00169-16